Oligonucleotide libraries--variatio delectat.

Variatio Delectat Consumer Demand for Food Diversity

Whereas a large number of empirical studies have been devoted to analysing consumer demand for specific products, much less attention has been paid to the household’s demand for product variety (the number of different products consumed in a specific time period). This paper analyses consumer demand for food variety in Germany. The econometric analysis of 4.632 household in 1995 suggests, that ...

Generation of amplifiable genome-specific oligonucleotide probes and libraries.

Here we describe a process for the generation of oligonucleotide libraries representative of a given nucleic acid. Starting from at random pool of DNA oligonucleotides, the technique selects only those that hybridize to the nucleic acid template. This selection yields a highly specific library that represents an oligonucleotide image of the chosen template. The novel quality of this approach is...

Methods for the Preparation of Large Quantities of Complex Single-Stranded Oligonucleotide Libraries

Custom-defined oligonucleotide collections have a broad range of applications in fields of synthetic biology, targeted sequencing, and cytogenetics. Also, they are used to encode information for technologies like RNA interference, protein engineering and DNA-encoded libraries. High-throughput parallel DNA synthesis technologies developed for the manufacture of DNA microarrays can produce librar...

Identification of nuclear hormone receptor homologs by screening libraries with highly degenerate oligonucleotide probes.

Rational screening of oligonucleotide combinatorial libraries for drug discovery.

Combinatorial strategies offer the potential to generate and screen extremely large numbers of compounds and to identify individual molecules with a desired binding specificity or pharmacological activity. We describe a combinatorial strategy for oligonucleotides in which the library is generated and screened without using enzymes. Freedom from enzymes enables the use of oligonucleotide analogu...